Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis.
J Assoc Physicians India
; 57: 70-1, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19753763
ABSTRACT
Isoniazid (INH) is an integral component of treatment of tuberculosis. An acute overdose is potentially fatal and is characterized by the clinical triad of repetitive seizures unresponsive to the usual anticonvulsants, metabolic acidosis with a high anion gap and coma. The diagnosis of INH overdose should be considered in any patient who presents to emergency medical services (EMS) with the triad. We report a patient presenting with multiple generalised tonic clonic (GTC) convulsions with severe metabolic acidosis as a manifestation of INH toxicity.
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Base de dados:
MEDLINE
Assunto principal:
Estado Epiléptico
/
Acidose
/
Isoniazida
/
Antituberculosos
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Assoc Physicians India
Ano de publicação:
2009
Tipo de documento:
Article