Predictive value of cellular immune response in cervical cancer.
Rom J Morphol Embryol
; 50(4): 651-5, 2009.
Article
em En
| MEDLINE
| ID: mdl-19942961
ABSTRACT
UNLABELLED Despite recent advances in the immune mechanisms of cervical cancer (CC), the relapse still remains an actual issue and recognition of new predictive biomarkers is essential. AIM:
The purpose of this retrospective study was to investigate possible differences in the primary, in situ, cellular immune response between cervical carcinoma with and without relapse. MATERIAL ANDMETHODS:
Paraffin-embedded tissue samples from 61 consecutive women with CC (34 with and 27 without relapse) were immunostained for CD3, CD20 and CD45 cells. Immune cell profile densities were further assessed, assigning scores between 0 and 3 "0" meaning the absence of inflammatory infiltrate, "1+" low, "2+" intense and "3+" intense infiltrate with lymphoid follicles. Statistical analysis was performed in SPSS-13 software, p<0.05.RESULTS:
Statistically significant intra- and peri-tumoral low numbers of several immune cell subtypes are strongly associated with relapse of disease within three and five years in patients with CC (p<0.05); moreover, statistical significant correlations between immune cells and both free survival (CD3 r=0.382; CD20 r=0.404; CD45 r=0.376) and relapse (CD3 r=-0.408; CD20 r=-0.355; CD45 r=-0.354) have been demonstrated. Only CD3 was reported as predictive biomarker of relapse in CC (ANOVA, t-Student, p<0.05).CONCLUSIONS:
Major differences in the cellular immune response among patients with cervical cancer with and without relapse within three and five years have been demonstrated. CD3 may be used as potential prognostic biomarkers, whereas the results are promising for adjuvant immunotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma in Situ
/
Biomarcadores Tumorais
/
Neoplasias do Colo do Útero
/
Complexo CD3
/
Recidiva Local de Neoplasia
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Rom J Morphol Embryol
Assunto da revista:
ANATOMIA
/
EMBRIOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Romênia