The biocompatability of mesoporous inorganic-organic hybrid resin films with ionic and hydrophilic characteristics.
Biomaterials
; 31(9): 2517-25, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-20045180
ABSTRACT
New mesoporous silicate-titania resin systems hybridized with 4,5-dihydroxy-m-benzenedisulfonic acid and poly(ethylene glycol)-dimethacrylate component were developed. These inorganic-organic hybrid resins were found to reveal highly controlled ionic and hydrophilic surface with excellent durability and adhesion onto various substrates. The resin films revealed high resistance to nonspecific adsorption of fibrinogen and to adherence by several bacterial pathogens such as Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis. Furthermore, excellent biocompatibility of the developed resins was proved by both HEp-2 cell adhesion in vitro and subcutaneous implantation in mice. The inorganic-organic hybrid resins are strongly promising for biomedical applications including biomedical devices and biosensors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
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Resinas Sintéticas
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Benzenossulfonatos
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Materiais Biocompatíveis
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Teste de Materiais
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Metacrilatos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biomaterials
Ano de publicação:
2010
Tipo de documento:
Article