Combined correction of recovery effect and motion blur for SUV quantification of solitary pulmonary nodules in FDG PET/CT.
Eur Radiol
; 20(8): 1868-77, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20306084
ABSTRACT
OBJECTIVE:
We evaluate a fully data-driven method for the combined recovery and motion blur correction of small solitary pulmonary nodules (SPNs) in F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT).METHODS:
The SPN was segmented in the low-dose CT using a variable Hounsfield threshold and morphological constraints. The combined effect of limited spatial resolution and motion blur in the SPN's PET image was then modelled by an effective Gaussian point-spread function (psf). Both isotropic and non-isotropic psfs were used. To validate the method, PET/CT measurements of the NEMA/IEC spheres phantom were performed. The method was applied to 50 unselected SPNsRESULTS:
Recovery of standardised uptake value (SUV) in the phantom image was significantly improved by combined recovery and motion blur correction compared with recovery-only correction, particularly with the non-isotropic model (residual average error 10%). In the patient images, automated segmentation and fit of the effective psf worked properly in all cases. Volume-equivalent diameter ranged from 4.9 to 27.8 mm. Uncorrected maximum SUV ranged from 0.9 to 13.3. Compared with recovery-only correction, combined correction with the non-isotropic model resulted in a 'relevant' (>or=30%) SUV increase in 47 SPNs (94%).CONCLUSIONS:
Correction of both recovery and motion blur is mandatory for accurate SUV quantification of SPNs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
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Interpretação de Imagem Assistida por Computador
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Aumento da Imagem
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Tomografia Computadorizada por Raios X
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Artefatos
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Nódulo Pulmonar Solitário
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Fluordesoxiglucose F18
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Neoplasias Pulmonares
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha