Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity.
Am J Obstet Gynecol
; 203(1): 40.e1-8, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20417479
ABSTRACT
OBJECTIVE:
The aim of this study was to determine whether sonographic fetal pulmonary artery flow velocity waveforms correlate with amniotic fluid biomarkers of fetal lung maturity. STUDYDESIGN:
We studied women with singleton pregnancies undergoing clinically indicated amniocentesis for fetal lung maturity at Yale-New Haven Hospital. Fetal pulmonary artery flow velocity measurements, including systolic/diastolic ratio, pulsatility index, resistance index, and acceleration-time/ejection-time ratio were obtained using spectral Doppler ultrasound. Pearson's correlation coefficient was used to determine the association between fetal pulmonary artery flow velocity parameters and the lecithin/sphingomyelin ratio.RESULTS:
Twenty-nine subjects met study criteria. The acceleration-time/ejection-time ratio was inversely correlated with the lecithin/sphingomyelin ratio (r = -0.76; P < or = .001). This relationship was maintained after controlling for potential confounders. Other fetal pulmonary artery flow velocity measurements were not associated with the lecithin/sphingomyelin ratio.CONCLUSION:
There is an inverse correlation between the acceleration-time/ejection-time ratio in the fetal pulmonary artery and the amniotic fluid lecithin/sphingomyelin ratio. This suggests that ultrasound evaluation of fetal pulmonary artery blood flow may be a promising new noninvasive technique to evaluate fetal lung maturity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Artéria Pulmonar
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Síndrome do Desconforto Respiratório do Recém-Nascido
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Ultrassonografia Pré-Natal
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Maturidade dos Órgãos Fetais
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Pulmão
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
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Incidence_studies
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Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos