Insulinomimetic activity of two new gallotannins from the fruits of Capparis moonii.
Bioorg Med Chem
; 18(11): 3940-5, 2010 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-20452777
ABSTRACT
Bioassay guided fractionation of the hydro-alcoholic extract of the fruits of Capparis moonii, led to the isolation of two new chebulinic acid derivatives. The compounds 1 and 2 displayed significant glucose uptake effect of 223% and 219% over the control at the 10ng/ml and 100ng/ml concentration, respectively. The increased glucose uptake effects of the compounds were associated with significant IR and IRS-1 phosphorylation, GLUT4 and PI3-kinase mRNA expression in the L6 cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Capparis
/
Taninos Hidrolisáveis
/
Glucose
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Índia