The synthesis of puerarin derivatives and their protective effect on the myocardial ischemia and reperfusion injury.
J Asian Nat Prod Res
; 12(10): 843-50, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20924897
ABSTRACT
Puerarin is a naturally occurring isoflavone and is frequently used for the treatment of cardiovascular symptoms in China. By the structural modification of the puerarin molecule at different positions, seven new puerarin derivatives were obtained, and their cardioprotective activities (in vitro and in vivo) were respectively evaluated. The finding that the activities of 3 and 8 markedly exceeded puerarin suggested that the acylated modification of phenolic hydroxyl at C-7 in the puerarin molecule may improve the cardioprotective activity, which will be an important reference for further structural optimization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cardiotônicos
/
Traumatismo por Reperfusão
/
Isquemia Miocárdica
/
Isoflavonas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Asian Nat Prod Res
Assunto da revista:
BOTANICA
/
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China