Predictive biomarkers in the management of EGFR mutant lung cancer.
Ann N Y Acad Sci
; 1210: 45-52, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20973798
ABSTRACT
Activating mutations in the form of deletions in exon 19 (del 19) or the missense mutation L858R in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) predict outcome to use of EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. Pooled data from several phase II studies show that gefitinib and erlotinib induce responses in over 70% of NSCLC patients harboring EGFR mutations, with progression-free survival (PFS) ranging from 9 to 13 months. Two studies in Caucasian and Asian patients have confirmed that these subgroups of patients attain PFS up to 14 months. These landmark outcomes have been accompanied by new challenges, primarily the additional role of chemotherapy and the management of tumors with the secondary T790M mutation that confers resistance to EGFR TKIs. Mechanisms of resistance to reversible EGFR TKIs should be further clarified and could be related to modifications in DNA repair.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Deleção de Sequência
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Receptores ErbB
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Neoplasias Pulmonares
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Mutação
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha