Candimine-induced cell death of the amitochondriate parasite Trichomonas vaginalis.
J Nat Prod
; 73(12): 2019-23, 2010 Dec 27.
Article
em En
| MEDLINE
| ID: mdl-21105684
ABSTRACT
Candimine (1), an alkaloid from the bulbs of Hippeastrum morelianum, was found to be cytotoxic for the amitochondriate parasite Trichomonas vaginalis. Candimine (1) induced cell death with an unprecedented group of effects that failed to fulfill the criteria for apoptosis and apoptosis-like death already reported in trichomonads. Arrest of the parasite cell cycle, and morphologic and ultrastructural alterations, including marked cytoplasmic vacuolization, were induced by 1. The present findings suggest some similarities to paraptotic cell death, described for multicellular organisms. This study contributes to both a better understanding of the biological effects of 1 and T. vaginalis cell biology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trichomonas vaginalis
/
Morte Celular
/
Liliaceae
/
Alcaloides
/
Antiprotozoários
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Brasil