The expression of peroxisomal protein transcripts increased by retinoic acid during neural differentiation.
Differentiation
; 81(2): 127-32, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21145646
ABSTRACT
Peroxisomal matrix protein is mainly expressed in heart, skeletal muscle, and brain tissues. To study the expression of peroxisomal protein (PEP) during neurogenesis, we employed mouse embryonic carcinoma cells (P19) and embryonic stem cells (mESCs) as an in vitro model for neural differentiation by retinoic acid (RA) induction. Expression pattern of PEP was investigated under distinct steps of differentiation by RT-PCR and real-time PCR. The results revealed that expression of PEP transcripts was markedly increased after the RA treatment at embryoid body and neural stages. Therefore, we concluded that PEP might be involved in the early process of neurogenesis, which needs further verification.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Tretinoína
/
Peroxissomos
/
Neurogênese
Limite:
Animals
Idioma:
En
Revista:
Differentiation
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Irã