Endurance factors improve hippocampal neurogenesis and spatial memory in mice.
Learn Mem
; 18(2): 103-7, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21245211
ABSTRACT
Physical activity improves learning and hippocampal neurogenesis. It is unknown whether compounds that increase endurance in muscle also enhance cognition. We investigated the effects of endurance factors, peroxisome proliferator-activated receptor δ agonist GW501516 and AICAR, activator of AMP-activated protein kinase on memory and neurogenesis. Mice were injected with GW for 7 d or AICAR for 7 or 14 d. Two weeks thereafter mice were tested in the Morris water maze. AICAR (7 d) and GW improved spatial memory. Moreover, AICAR significantly, and GW modestly, elevated dentate gyrus neurogenesis. Thus, pharmacological activation of skeletal muscle may mediate cognitive effects.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ribonucleotídeos
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Tiazóis
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Neurogênese
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Aminoimidazol Carboxamida
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Hipocampo
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Memória
Limite:
Animals
Idioma:
En
Revista:
Learn Mem
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos