Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells.
Microbiol Immunol
; 55(2): 135-40, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21265875
ABSTRACT
Dengue viruses infect cells by attaching to a surface receptor which remains unknown. The putative receptor molecules of dengue virus type 2 on the surface of mosquito (AP-61) and mammalian (LLC-MK2) cell lines were investigated. The immunochemical detection and structural analysis of carbohydrates demonstrated that the neutral glycosphingolipids, L-3 (GlcNAcß1-3Manß1-4Glcß1-1'Cer) in AP-61 cells, and nLc(4) Cer (Galß1-4GlcNAcß1-3Galß1-4Glcß1-1'Cer) in LLC-MK2 cells were recognized by the virus. These findings strongly suggest that neutral glycosphingolipids share the key determinant for virus binding and that the ß-GlcNAc residue may play an important role in dengue virus binding to the host cell surface.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicoesfingolipídeos Neutros
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Dengue
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Vírus da Dengue
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Insetos Vetores
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Mamíferos
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Culicidae
Limite:
Animals
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Humans
Idioma:
En
Revista:
Microbiol Immunol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Tailândia