Fused heterocyclic amido compounds as anti-hepatitis C virus agents.
Bioorg Med Chem
; 19(8): 2675-87, 2011 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-21458278
ABSTRACT
We identified a fused heteroaromatic amido structure based on the phenanthridine skeleton as a superior scaffold for candidate drugs with potent anti-HCV activity. Among the compounds synthesized, a phenanthridine analogue with a 1,3-dioxolyl group (24) possessed the most potent anti-HCV activity (EC(50) value 50 nM), with acceptable cytotoxicity. The structural development and structure-activity relationships of these compounds are described.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Fenantridinas
/
Hepacivirus
/
Compostos Heterocíclicos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão