Leptin, fat mass, and bone mineral density in healthy pre- and postmenopausal women.
J Clin Densitom
; 14(3): 321-5, 2011.
Article
em En
| MEDLINE
| ID: mdl-21600824
ABSTRACT
The purpose was to examine relationships between age, fat mass, and bone mineral density (BMD) with resting leptin levels in premenopausal and postmenopausal women. Young (aged 18-30 yr, n=30) and estrogen-deficient postmenopausal (aged 55-75 yr, n=43) women were recruited. Total body and segmental fat mass and bone-free lean body mass (BFLBM) and total body, lumbar spine, and proximal femur BMD were assessed using dual-energy X-ray absorptiometry. Serum-resting, fasted leptin levels were measured by Immunoradiometric Assay (IRMA), and leptin-to-fat mass ratios were calculated. Young and older women had similar amounts of BFLBM, but older women had greater (p<0.05) amounts of fat mass and 35% higher leptin levels. Age differences in leptin concentrations were no longer significant after controlling for fat mass. Older women had significantly (p<0.05) lower hip BMD values. Age was negatively related (r=-0.29, p<0.05) to leptintrunk fat ratio. Increases in fat mass, not menopause per se, contributes to higher leptin levels in older women. Relationships between leptin and BMD may be age dependent.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Absorciometria de Fóton
/
Densidade Óssea
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Pré-Menopausa
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Pós-Menopausa
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Leptina
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Distribuição da Gordura Corporal
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
J Clin Densitom
Assunto da revista:
ORTOPEDIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos