Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.

Yeang, Han Xian Aw; Hamdam, Junnat M; Al-Huseini, Laith M A; Sethu, Swaminathan; Djouhri, Laiche; Walsh, Joanne; Kitteringham, Neil; Park, B Kevin; Goldring, Christopher E; Sathish, Jean G

Yeang, Han Xian Aw; Hamdam, Junnat M; Al-Huseini, Laith M A; Sethu, Swaminathan; Djouhri, Laiche; Walsh, Joanne; Kitteringham, Neil; Park, B Kevin; Goldring, Christopher E; Sathish, Jean G.

Afiliação

Yeang HXA; Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.
Hamdam JM; Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.
Al-Huseini LMA; Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.
Sethu S; Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.
Djouhri L; Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.
Walsh J; Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.
Kitteringham N; Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.
Park BK; Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.
Goldring CE; Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom. Electronic address: chrissy@liv.ac.uk.
Sathish JG; Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom. Electronic address: Jean.Sathish@liv.ac.uk.

J Biol Chem ; 287(13): 10556-10564, 2012 Mar 23.

Article em En | MEDLINE | ID: mdl-22311972

Assuntos

Células Dendríticas/metabolismo; Homeostase/fisiologia; Sistema de Sinalização das MAP Quinases/fisiologia; Fator 2 Relacionado a NF-E2/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Animais; Linfócitos T CD8-Positivos/metabolismo; Células Dendríticas/citologia; Glutationa/genética; Glutationa/metabolismo; Histona Desacetilases/genética; Histona Desacetilases/metabolismo; Camundongos; Camundongos Knockout; Fator 2 Relacionado a NF-E2/genética; NF-kappa B/genética; NF-kappa B/metabolismo; Oxirredução; Proteínas Quinases p38 Ativadas por Mitógeno/genética; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Dendríticas / Espécies Reativas de Oxigênio / Sistema de Sinalização das MAP Quinases / Fator 2 Relacionado a NF-E2 / Homeostase Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Reino Unido

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