Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon.
Cell Biochem Funct
; 30(4): 271-8, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22315045
ABSTRACT
Triptolide is a diterpenoid triepoxide derived from the traditional Chinese medical herb Tripterygium wilfordii. In the present study, we demonstrated that this phytochemical attenuated colon cancer growth in vitro and in vivo. Using a proteomic approach, we found that 14-3-3 epsilon, a cell cycle- and apoptosis-related protein, was altered in colon cancer cells treated with triptolide. In this regard, triptolide induced cleavage and perinuclear translocation of 14-3-3 epsilon. Taken together, our findings suggest that triptolide may merit investigation as a potential therapeutic agent for colon cancer, and its anticancer action may be associated with alteration of 14-3-3 epsilon.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenantrenos
/
Antineoplásicos Alquilantes
/
Proteínas 14-3-3
/
Diterpenos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Biochem Funct
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China