The Suzuki reaction applied to the synthesis of novel pyrrolyl and thiophenyl indazoles.
Molecules
; 17(4): 4508-21, 2012 Apr 16.
Article
em En
| MEDLINE
| ID: mdl-22508331
ABSTRACT
The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K(2)CO(3), dimethoxyethane and Pd(dppf)Cl(2) as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Tiofenos
/
Indazóis
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália