Azole interactions with multidrug therapy in pediatric oncology.
Eur J Clin Pharmacol
; 69(1): 1-10, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-22660443
ABSTRACT
Patients with cancer receive multidrug therapy. Antineoplastic agents and supportive care drugs are often administered together, leading to potential drug-drug interactions. These interactions may have significant clinical implications in terms of toxicity or a decrease in the efficacy of the treatment administered. Here, we focus on the role of azoles and their main pharmacokinetic interactions with the principal classes of drugs used in pediatric oncology. The co-administration of azoles and antineoplastic agents, corticosteroids, immunosuppressants, antacids, antiemetics, antiepileptic drugs and analgesics was investigated, and a practical guide on the management of these drugs when administered together is provided.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Azóis
/
Interações Medicamentosas
/
Neoplasias
Limite:
Child
/
Humans
Idioma:
En
Revista:
Eur J Clin Pharmacol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália