Challenges and opportunities for oncology biomarker discovery.
Drug Discov Today
; 18(13-14): 614-24, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23280501
ABSTRACT
Recent success of companion diagnostics along with the increasing regulatory pressure for better identification of the target population has created an unprecedented incentive for drug discovery companies to invest in novel strategies for biomarker discovery. In parallel with the rapid advancement and clinical adoption of high-throughput technologies, a number of knowledge management and systems biology approaches have been developed to analyze an ever increasing collection of OMICs data. This review discusses current biomarker discovery technologies highlighting challenges and opportunities of knowledge capturing and presenting a perspective of the future integrative modeling approaches as an emerging trend in biomarker prediction.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Pesquisa Biomédica
/
Oncologia
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Discov Today
Assunto da revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Alemanha