Broadly neutralizing antiviral antibodies.
Annu Rev Immunol
; 31: 705-42, 2013.
Article
em En
| MEDLINE
| ID: mdl-23330954
A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive immune response. The widely held view has been that the great variability of viral glycoproteins would be an absolute obstacle to the development of antibody-based therapies or vaccines that could confer broad and long-lasting protection. In the past five years, new approaches have been developed to interrogate human memory B cells and plasma cells with high efficiency and to isolate several broadly neutralizing antiviral antibodies against highly variable pathogens such as HIV-1 and influenza virus. These antibodies not only provide new tools for prophylaxis and therapy for viral diseases but also identify conserved epitopes that may be used to design new vaccines capable of conferring broader protection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Testes de Neutralização
/
Anticorpos Antivirais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Immunol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Suíça