Three times spontaneous remission of severe aplastic anemia following granulocyte transfusion from related donors: a case report and literature review.
Chin Med Sci J
; 28(1): 58-60, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23527810
ABSTRACT
Aplastic anemia (AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes, resulting in the apoptosis of hematopoietic cells and bone marrow failure. Currently, hematopoietic stem cell transplantation (HSCT), immunosuppressive - therapy (IST), and supportive care (e.g. transfusion adjuvant therapy, hematopoietic growth factors, and prevention of infection) are the main treatments of AA. Granulocyte transfusion has recently been accepted as an useful adjuvant therapy of HSCT and intensive IST. This article reported a severe AA patient who failed to respond to IST, but achieved spontaneous remission three times after granulocyte transfusions from related donors. Such cases have rarely been reported. Existence of human leukocyte antigen (HLA) cross between the patient and his relatives may influence the T cell-mediated immunity, which might explain this patient's recovery.
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Base de dados:
MEDLINE
Assunto principal:
Transfusão de Leucócitos
/
Granulócitos
/
Anemia Aplástica
Tipo de estudo:
Systematic_reviews
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Chin Med Sci J
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China