Phthalates in the NICU: is it safe?
J Paediatr Child Health
; 49(9): E413-9, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23714420
ABSTRACT
AIMS:
As growing concerns exist regarding phthalate exposure, which could be teratogenic, carcinogenic or induce reproductive toxicity, we aimed to review the evidence of the risks due to the use of medical devices containing di(2-ethylhexyl)phthalate in hospitalized neonates.METHODS:
We reviewed the literature, searching through medical literature databases (Pubmed, MEDLINE, EBM reviews, Cochrane database, Embase and Google Scholar) using the following keywords phthalate, di(2-ethylhexyl)phthalate, newborn and neonate.RESULTS:
We identified several associations with short and long term health dangers, mainly subfertility, broncho-pulmonary dysplasia, necrotising enterocolitis, parenteral nutrition associated cholestasis and neuro-developmental disorders. These data are based mainly on animal or observational human studies.CONCLUSION:
Clinicians must be aware of the potential risks due to phthalate exposure in the NICU. Di(2-ethylhexyl)phthalate containing materials should be identified and alternative devices should be considered. There is a need to improve knowledge in this area.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plastificantes
/
Unidades de Terapia Intensiva Neonatal
/
Dietilexilftalato
/
Exposição Ambiental
Tipo de estudo:
Guideline
/
Prognostic_studies
/
Systematic_reviews
Limite:
Animals
/
Female
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Humans
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Newborn
/
Pregnancy
Idioma:
En
Revista:
J Paediatr Child Health
Assunto da revista:
PEDIATRIA
Ano de publicação:
2013
Tipo de documento:
Article