Protein kinase G oxidation is a major cause of injury during sepsis.
Proc Natl Acad Sci U S A
; 110(24): 9909-13, 2013 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-23716652
ABSTRACT
Sepsis is a common life-threatening clinical syndrome involving complications as a result of severe infection. A cardinal feature of sepsis is inflammation that results in oxidative stress. Sepsis in wild-type mice induced oxidative activation of cGMP-dependent protein kinase 1 alpha (PKG Iα), which increased blood vessel dilation and permeability, and also lowered cardiac output. These responses are typical features of sepsis and their combined effect is a lowering of blood pressure. This hypotension, a hallmark of sepsis, resulted in underperfusion of end organs, resulting in their damage. A central role for PKG Iα oxidative activation in injury is supported by oxidation-resistant Cys42Ser PKG Iα knock-in mice being markedly protected from these clinical indices of injury during sepsis. We conclude that oxidative activation of PKG Iα is a key mediator of hypotension and consequential organ injury during sepsis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sepse
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Proteína Quinase Dependente de GMP Cíclico Tipo I
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Hipotensão
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Insuficiência de Múltiplos Órgãos
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Reino Unido