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Differential expression of αB-crystallin causes maturation-dependent susceptibility of oligodendrocytes to oxidative stress.
Kim, Ji Young; Lee, Eun Young; Sohn, Hyun Joon; Kim, Si Wook; Kim, Chan Hyung; Ahn, Hee Yul; Kim, Dong Woon; Cho, Sa Sun; Seo, Je Hoon.
Afiliação
  • Kim JY; Departments of Anatomy, Chungbuk National University School of Medicine, Cheongju 361-763, Korea seojh@chungbuk.ac.kr.
BMB Rep ; 46(10): 501-6, 2013 Oct.
Article em En | MEDLINE | ID: mdl-24148771
Oligodendrocyte precursor cells (OPCs) are most susceptible to oxidative stress in the brain. However, the cause of differences in susceptibility to oxidative stress between OPCs and mature oligodendrocytes (mOLs) remains unclear. Recently, we identified in vivo that αB-crystallin (aBC) is expressed in mOLs but not in OPCs. Therefore, we examined in the present study whether aBC expression could affect cell survival under oxidative stress induced by hydrogen peroxide using primary cultures of OPCs and mOLs from neonatal rat brains. Expression of aBC was greater in mOLs than in OPCs, and the survival rate of mOLs was significantly higher than that of OPCs under oxidative stress. Suppression of aBC by siRNA transfection resulted in a decrease in the survival rate of mOLs under oxidative stress. These data suggest that higher susceptibility of OPCs than mOLs to oxidative stress is due, at least in part, to low levels of aBC expression.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligodendroglia / Cristalinas Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: BMB Rep Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligodendroglia / Cristalinas Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: BMB Rep Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2013 Tipo de documento: Article