Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection.
Drug Discov Today Technol
; 10(4): e517-22, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24451643
ABSTRACT
The interaction between lens epithelium-derived growth factor (LEDGF/p75) and HIV-1 integrase (IN) is an attractive target for antiviral development because its inhibition blocks HIV replication. Developing novel small molecules that disrupt the LEDGF/p75-IN interaction constitutes a promising new therapeutic strategy for the treatment of HIV. Here we will highlight recent advances in the design and development of small-molecule inhibitors binding to the LEDGF/p75 binding pocket of IN, referred to as LEDGINs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Infecções por HIV
/
Inibidores de Integrase de HIV
/
Integrase de HIV
/
Proteínas Adaptadoras de Transdução de Sinal
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Drug Discov Today Technol
Ano de publicação:
2013
Tipo de documento:
Article