Acylated and unacylated ghrelin administration to blunt muscle wasting.
Curr Opin Clin Nutr Metab Care
; 17(3): 236-40, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24572833
ABSTRACT
PURPOSE OF REVIEW Muscle wasting is a comorbidity often associated with a wide range of disorders that severely affects patient prognosis and quality of life. Ghrelin, through its receptor GHSR-1a, stimulates appetite and growth hormone (GH) release. Several studies indicate that ghrelin administration is a valid treatment for cachexia because it improves muscle mass and function, likely by restoring a positive energy balance. RECENT FINDINGS:
In addition to its GHSR-1a-mediated effects on muscle mass, ghrelin acts directly on skeletal muscle, wherein it exerts a protective activity against muscle wasting. This direct activity is independent of GHSR-1a and is shared by the unacylated form of ghrelin, which does not bind GHSR-1a and is devoid of the effects on appetite and GH release.SUMMARY:
Both the acylated and unacylated forms of ghrelin might have therapeutic potential for the treatment of skeletal muscle wasting.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Atrofia Muscular
/
Síndrome de Emaciação
/
Grelina
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Clin Nutr Metab Care
Assunto da revista:
CIENCIAS DA NUTRICAO
/
METABOLISMO
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Itália