Myocardial effects of calcium cyclamate in the BIO F1D Alexander Syrian golden hamster.
Exp Pathol
; 34(1): 23-7, 1988.
Article
em En
| MEDLINE
| ID: mdl-2465174
ABSTRACT
In a subchronic 90-day oral toxicity study, 5 groups (20 males, 20 females each) of F2-descendants of BIO F1D Alexander hamsters received 0, 275, 550, 1,100 and 2,200 mg/kg b.w./day doses, respectively, of calcium cyclamate in the drinking water. These doses caused no adverse health effects in any treated animal and the multifocal myocardial calcifications, detectable at a 100% incidence in the male and female control hamsters (20 males, 20 females), were not exacerbated by the sweetener. Instead, the myocardial lesions exhibited a striking negative dose-response relationship with a 0% incidence in the males and a 5% incidence in the female hamsters of the highest dose group.
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Base de dados:
MEDLINE
Assunto principal:
Ciclamatos
/
Coração
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Exp Pathol
Ano de publicação:
1988
Tipo de documento:
Article