A novel functional TagSNP Rs7560488 in the DNMT3A1 promoter is associated with susceptibility to gastric cancer by modulating promoter activity.

Wu, Huazhang; Zhang, Kun; Gong, Pihai; Qiao, Fengchang; Wang, Ling; Cui, He; Sui, Xinyuan; Gao, Jifan; Fan, Hong

Wu, Huazhang; Zhang, Kun; Gong, Pihai; Qiao, Fengchang; Wang, Ling; Cui, He; Sui, Xinyuan; Gao, Jifan; Fan, Hong.

Afiliação

Wu H; The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China.
Zhang K; The Third Affiliated Hospital of Harbin Medical University (Harbin Medical University Cancer Hospital), Harbin, China.
Gong P; The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China.
Qiao F; The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China.
Wang L; The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China.
Cui H; The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China.
Sui X; The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China.
Gao J; The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China.
Fan H; The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China.

PLoS One ; 9(3): e92911, 2014.

Article em En | MEDLINE | ID: mdl-24667323

Assuntos

DNA (Citosina-5-)-Metiltransferases/genética; Predisposição Genética para Doença/genética; Polimorfismo de Nucleotídeo Único; Regiões Promotoras Genéticas/genética; Neoplasias Gástricas/enzimologia; Neoplasias Gástricas/genética; Adulto; Idoso; Idoso de 80 Anos ou mais; Envelhecimento/genética; Alelos; Povo Asiático/genética; Sequência de Bases; DNA Metiltransferase 3A; Feminino; Regulação Neoplásica da Expressão Gênica/genética; Projeto HapMap; Humanos; Masculino; Pessoa de Meia-Idade; Fator de Transcrição AP-1/metabolismo; Transcrição Gênica/genética; Adulto Jovem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Regiões Promotoras Genéticas / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / DNA (Citosina-5-)-Metiltransferases Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China

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