[Parenchymal neuro-Behcet's disease. Clinical and paraclinical characteristics, a report of 40 cases]. / Neuro-Behçet dans sa forme parenchymateuse. Caractéristiques cliniques et paracliniques (40 cas).
Presse Med
; 43(5): e119-25, 2014 May.
Article
em Fr
| MEDLINE
| ID: mdl-24703735
ABSTRACT
OBJECTIVE:
Describe the clinical and paraclinical characteristics of parenchymal neuro-Behcet's disease.METHODS:
This is a prospective, descriptive study, concerning 40 patients with parenchymal neuro-Behcet's disease. The patients were followed during 3 years, benefited a thorough physical examination and paraclinical made of inflammatory laboratory tests, infectious serology, serum/CSF autoimmunity assessment, brain/spine MRI and evoked potentials. We also evaluated the frequency of HLA-B51.RESULTS:
We identified 22 men and 18 women. The average age was 32 years. The beginning was poly-symptomatic in 65% cases. Twenty-eight patients (70%) reported a decrease in visual acuity, 40% (16 cases) associated with uveitis, 33 cases (82.5%) complained of headache and 11 cases (27.5%) with dizziness. Inaugural signs consisted of motor disorders (50%) and balance disorders (40%). The inflammatory serum markers were positive in 75% and oligoclonal bands present in CSF were found in 7 patients. Infracentimetric demyelinating lesions in MRI study were located in the brainstem (52.5%), the subcortical white matter (40%), the periventricular region (42.5%), cerebellum (32.5%), basal ganglia (30%), internal capsule (25%) and corpus callosum (12.5%). The HLA-B51 was found in 53% of cases.CONCLUSION:
Behçet's disease mainly affects young male. The neurological complications are highly polymorphic, involving severe vital or functional prognosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Behçet
/
Doenças do Sistema Nervoso
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Fr
Revista:
Presse Med
Ano de publicação:
2014
Tipo de documento:
Article