Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys.
Invest Ophthalmol Vis Sci
; 55(5): 3067-73, 2014 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-24736050
ABSTRACT
PURPOSE:
To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head.METHODS:
This experimental study included nine monkeys that underwent implantation of a lumbar-peritoneal cerebrospinal fluid (CSF) shunt. In the study group (n = 4 monkeys), the shunt was opened to achieve a CSF of approximately 40 mm H2O, while the shunt remained closed in the control group (n = 5 monkeys). At baseline and in monthly intervals thereafter, optical coherence tomographic and photographic images of the optic nerve head and RNFL were taken of all monkeys.RESULTS:
Two out of four monkeys in the study group showed bilaterally a progressive reduction in RNFL thickness between 12% and 30%, reduction in neuroretinal rim area and volume, and increase in cup-to-disc area ratios. A third monkey developed a splinter-like disc hemorrhage in one eye. The fourth monkey in the study group did not develop morphologic changes during follow-up, nor did any monkey in the control group.CONCLUSIONS:
Experimental and chronic reduction in CSF in monkeys was associated with the development of an optic neuropathy in some monkeys.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pressão do Líquido Cefalorraquidiano
/
Doenças do Nervo Óptico
/
Glaucoma
Limite:
Animals
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China