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Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor.
Shi, Jiong; Zhou, Jing; Halambage, Upul D; Shah, Vaibhav B; Burse, Mallori J; Wu, Hua; Blair, Wade S; Butler, Scott L; Aiken, Christopher.
Afiliação
  • Shi J; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Zhou J; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Halambage UD; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Shah VB; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Burse MJ; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Wu H; Department of Virology, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, USA.
  • Blair WS; Department of Virology, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, USA.
  • Butler SL; Department of Virology, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, USA.
  • Aiken C; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA chris.aiken@vanderbilt.edu.
J Virol ; 89(1): 208-19, 2015 Jan.
Article em En | MEDLINE | ID: mdl-25320302
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilalanina / Replicação Viral / HIV-1 / Proteína do Núcleo p24 do HIV / Fármacos Anti-HIV / Substituição de Aminoácidos / Farmacorresistência Viral / Indóis Tipo de estudo: Health_economic_evaluation / Risk_factors_studies Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilalanina / Replicação Viral / HIV-1 / Proteína do Núcleo p24 do HIV / Fármacos Anti-HIV / Substituição de Aminoácidos / Farmacorresistência Viral / Indóis Tipo de estudo: Health_economic_evaluation / Risk_factors_studies Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos