Evaluation of the role of ATP-binding cassette transporters as a defence mechanism against temephos in populations of Aedes aegypti.
Mem Inst Oswaldo Cruz
; 109(7): 964-6, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25411004
ABSTRACT
The role of ATP-binding cassette (ABC) transporters in the efflux of the insecticide, temephos, was assessed in the larvae of Aedes aegypti. Bioassays were conducted using mosquito populations that were either susceptible or resistant to temephos by exposure to insecticide alone or in combination with sublethal doses of the ABC transporter inhibitor, verapamil (30, 35 and 40 µM). The best result in the series was obtained with the addition of verapamil (40 µM), which led to a 2x increase in the toxicity of temephos, suggesting that ABC transporters may be partially involved in conferring resistance to the populations evaluated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Temefós
/
Resistência a Inseticidas
/
Transportadores de Cassetes de Ligação de ATP
/
Aedes
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Insetos Vetores
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Inseticidas
Limite:
Animals
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil