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Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study.
Lalonde, Emilie; Ishkanian, Adrian S; Sykes, Jenna; Fraser, Michael; Ross-Adams, Helen; Erho, Nicholas; Dunning, Mark J; Halim, Silvia; Lamb, Alastair D; Moon, Nathalie C; Zafarana, Gaetano; Warren, Anne Y; Meng, Xianyue; Thoms, John; Grzadkowski, Michal R; Berlin, Alejandro; Have, Cherry L; Ramnarine, Varune R; Yao, Cindy Q; Malloff, Chad A; Lam, Lucia L; Xie, Honglei; Harding, Nicholas J; Mak, Denise Y F; Chu, Kenneth C; Chong, Lauren C; Sendorek, Dorota H; P'ng, Christine; Collins, Colin C; Squire, Jeremy A; Jurisica, Igor; Cooper, Colin; Eeles, Rosalind; Pintilie, Melania; Dal Pra, Alan; Davicioni, Elai; Lam, Wan L; Milosevic, Michael; Neal, David E; van der Kwast, Theodorus; Boutros, Paul C; Bristow, Robert G.
Afiliação
  • Lalonde E; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Ishkanian AS; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, USA.
  • Sykes J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Fraser M; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Ross-Adams H; Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
  • Erho N; Research and Development, GenomeDx Biosciences, Vancouver, BC, Canada.
  • Dunning MJ; Bioinformatics Core, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
  • Halim S; Bioinformatics Core, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
  • Lamb AD; Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK; Department of Urology, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge, UK.
  • Moon NC; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Zafarana G; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Warren AY; Department of Pathology, Addenbrooke's Hospital, Cambridge, UK.
  • Meng X; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Thoms J; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Grzadkowski MR; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Berlin A; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Have CL; Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada.
  • Ramnarine VR; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Vancouver Prostate Centre and Department of Urological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Yao CQ; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Malloff CA; Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.
  • Lam LL; Research and Development, GenomeDx Biosciences, Vancouver, BC, Canada.
  • Xie H; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Harding NJ; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Mak DYF; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Center for Addiction and Mental Health, Toronto, ON, Canada.
  • Chu KC; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Chong LC; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Sendorek DH; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • P'ng C; Informatics and Bio-Computing Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Collins CC; Vancouver Prostate Centre and Department of Urological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Squire JA; Department of Pathology and Forensic Medicine, University of São Paulo at Ribeirão Preto, Ribeirão Preto, Brazil.
  • Jurisica I; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Cooper C; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK; Department of Biological Sciences and School of Medicine, University of East Anglia, Norwich, UK.
  • Eeles R; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK; Royal Marsden National Health Service Foundation Trust, London, UK.
  • Pintilie M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Dal Pra A; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, Bern University Hospital, Bern, Switzerland.
  • Davicioni E; Research and Development, GenomeDx Biosciences, Vancouver, BC, Canada.
  • Lam WL; Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.
  • Milosevic M; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
  • Neal DE; Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK; Department of Urology, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge, UK.
  • van der Kwast T; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada.
  • Boutros PC; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
  • Bristow RG; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Electronic address: rob.bristow@rmp.uhn.on.ca.
Lancet Oncol ; 15(13): 1521-1532, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25456371
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Biomarcadores Tumorais / Perfilação da Expressão Gênica / Microambiente Tumoral / Recidiva Local de Neoplasia Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Lancet Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Canadá
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Biomarcadores Tumorais / Perfilação da Expressão Gênica / Microambiente Tumoral / Recidiva Local de Neoplasia Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Lancet Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Canadá