Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock.
Cell
; 159(6): 1253-62, 2014 Dec 04.
Article
em En
| MEDLINE
| ID: mdl-25480291
ABSTRACT
Normal energy metabolism is characterized by periodic shifts in glucose and fat oxidation, as the mitochondrial machinery responsible for carbon combustion switches freely between alternative fuels according to physiological and nutritional circumstances. These transitions in fuel choice are orchestrated by an intricate network of metabolic and cell signaling events that enable exquisite crosstalk and cooperation between competing substrates to maintain energy and glucose homeostasis. By contrast, obesity-related cardiometabolic diseases are increasingly recognized as disorders of metabolic inflexibility, in which nutrient overload and heightened substrate competition result in mitochondrial indecision, impaired fuel switching, and energy dysregulation. This Perspective offers a speculative view on the molecular origins and pathophysiological consequences of metabolic inflexibility.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome Metabólica
/
Metabolismo Energético
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2014
Tipo de documento:
Article