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A high-throughput RNAi screen for detection of immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes.
Khandelwal, Nisit; Breinig, Marco; Speck, Tobias; Michels, Tillmann; Kreutzer, Christiane; Sorrentino, Antonio; Sharma, Ashwini Kumar; Umansky, Ludmila; Conrad, Heinke; Poschke, Isabel; Offringa, Rienk; König, Rainer; Bernhard, Helga; Machlenkin, Arthur; Boutros, Michael; Beckhove, Philipp.
Afiliação
  • Khandelwal N; Division of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany n.khandelwal@dkfz.de p.beckhove@dkfz.de.
  • Breinig M; Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg University, Heidelberg, Germany.
  • Speck T; Division of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Michels T; Division of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Kreutzer C; Division of Immunogenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Sorrentino A; Division of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Sharma AK; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Umansky L; Division of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Conrad H; Division of Immunogenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Poschke I; Department of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center (DKFZ) and Division of Pancreas Carcinoma Research, Surgery Clinic of Heidelberg University, Heidelberg, Germany.
  • Offringa R; Department of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center (DKFZ) and Division of Pancreas Carcinoma Research, Surgery Clinic of Heidelberg University, Heidelberg, Germany.
  • König R; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC) Jena University Hospital, Jena, Germany Leibniz Institute for Natural Products Research and Infection Biology, Hans-Kn
  • Bernhard H; Department of Hematology/Oncology, Klinikum Darmstadt GmbH, Darmstadt, Germany.
  • Machlenkin A; Sharett Institute of Oncology, Hadassah-Hebrew University Hospital, Jerusalem, Israel.
  • Boutros M; Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg University, Heidelberg, Germany.
  • Beckhove P; Division of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany n.khandelwal@dkfz.de p.beckhove@dkfz.de.
EMBO Mol Med ; 7(4): 450-63, 2015 Apr.
Article em En | MEDLINE | ID: mdl-25691366
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Th1 / Linfócitos T CD8-Positivos / Interferência de RNA / Imunidade Celular / Imunoterapia / Neoplasias Experimentais Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: EMBO Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Th1 / Linfócitos T CD8-Positivos / Interferência de RNA / Imunidade Celular / Imunoterapia / Neoplasias Experimentais Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: EMBO Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2015 Tipo de documento: Article