Bioactive triterpenoids from Atriplex lasiantha.

Chromatographic purification of the ethyl acetate soluble fraction from the methanolic extract of Atriplex lasiantha yielded a new triterpenoid, 7ß,15α,16ß-trihydroxyolean-12-ene-28,30-dioic acid-3-O-ß-D-xylopyranoside (1), along with two known triterpenoids, rotundifolioside I (2) and corchorusin B (3). Structures of the compounds 1-3 were elucidated through sophisticated NMR studies and high resolution mass spectrometry. The three isolates (1-3) were evaluated for antibacterial, antioxidant, and antiurease activities. Compound 2 exhibited the best antibacterial activity against Escherichiacoli with IC50 value of 66.25 µg/ml, whereas, all the tested compounds exhibited antioxidant (IC50 values of 68.7-75.4 µg/ml) and antiurease (IC50 values of 25.5-49.3 µg/ml) activities, respectively.