Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.

Nguyen, Tuyet Thi; Quan, Xianglan; Hwang, Kyu-Hee; Xu, Shanhua; Das, Ranjan; Choi, Seong-Kyung; Wiederkehr, Andreas; Wollheim, Claes B; Cha, Seung-Kuy; Park, Kyu-Sang

Nguyen, Tuyet Thi; Quan, Xianglan; Hwang, Kyu-Hee; Xu, Shanhua; Das, Ranjan; Choi, Seong-Kyung; Wiederkehr, Andreas; Wollheim, Claes B; Cha, Seung-Kuy; Park, Kyu-Sang.

Afiliação

Nguyen TT; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;
Quan X; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;
Hwang KH; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;
Xu S; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;
Das R; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;
Choi SK; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;
Wiederkehr A; Nestlé Institute of Health Sciences, Lausanne, Switzerland, and.
Wollheim CB; Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
Cha SK; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea;
Park KS; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea; qsang@yonsei.ac.kr.

Am J Physiol Endocrinol Metab ; 308(11): E933-41, 2015 Jun 01.

Article em En | MEDLINE | ID: mdl-25852001

Assuntos

Apoptose/efeitos dos fármacos; Células Secretoras de Insulina/efeitos dos fármacos; Insulina/metabolismo; Mitocôndrias/metabolismo; Estresse Oxidativo/fisiologia; Fosfatos/farmacologia; Animais; Células Cultivadas; Secreção de Insulina; Células Secretoras de Insulina/fisiologia; Masculino; Proteínas de Transporte da Membrana Mitocondrial/efeitos dos fármacos; Proteínas de Transporte da Membrana Mitocondrial/metabolismo; Poro de Transição de Permeabilidade Mitocondrial; Fosfatos/metabolismo; Ratos; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/metabolismo; Espécies Reativas de Oxigênio/farmacologia; Superóxidos/metabolismo

Palavras-chave

ER stress; hyperphosphatemia; insulin secretion; mitochondrial permeability transition pore; superoxide

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatos / Apoptose / Estresse Oxidativo / Células Secretoras de Insulina / Insulina / Mitocôndrias Limite: Animals Idioma: En Revista: Am J Physiol Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Ano de publicação: 2015 Tipo de documento: Article

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