Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia.

Rolf, Nina; Kariminia, Amina; Ivison, Sabine; Reid, Gregor S; Schultz, Kirk R

Rolf, Nina; Kariminia, Amina; Ivison, Sabine; Reid, Gregor S; Schultz, Kirk R.

Afiliação

Rolf N; The Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute and Division of Pediatric Hem/Onc/BMT, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Kariminia A; The Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute and Division of Pediatric Hem/Onc/BMT, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Ivison S; The Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute and Division of Pediatric Hem/Onc/BMT, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Reid GS; The Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute and Division of Pediatric Hem/Onc/BMT, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Schultz KR; The Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute and Division of Pediatric Hem/Onc/BMT, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Eur J Immunol ; 45(7): 1980-90, 2015 Jul.

Article em En | MEDLINE | ID: mdl-25867213

Assuntos

Apoptose/imunologia; Lipopeptídeos/farmacologia; Leucemia-Linfoma Linfoblástico de Células Precursoras/imunologia; Receptor 2 Toll-Like/imunologia; Apoptose/efeitos dos fármacos; Antígenos CD40/imunologia; Linhagem Celular Tumoral; Citometria de Fluxo; Humanos; Leucemia-Linfoma Linfoblástico de Células Precursoras/patologia; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/imunologia; Receptor 2 Toll-Like/agonistas

Palavras-chave

CD40; Caspase-8-mediated apoptotic cell death; Heterodimer-specific TLR2 stimulation; Pediatric acute lymphoblastic leukemia; Signaling kinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Receptor 2 Toll-Like / Leucemia-Linfoma Linfoblástico de Células Precursoras / Lipopeptídeos Limite: Humans Idioma: En Revista: Eur J Immunol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Canadá

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