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Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.
Ong, Christy C; Gierke, Sarah; Pitt, Cameron; Sagolla, Meredith; Cheng, Christine K; Zhou, Wei; Jubb, Adrian M; Strickland, Laura; Schmidt, Maike; Duron, Sergio G; Campbell, David A; Zheng, Wei; Dehdashti, Seameen; Shen, Min; Yang, Nora; Behnke, Mark L; Huang, Wenwei; McKew, John C; Chernoff, Jonathan; Forrest, William F; Haverty, Peter M; Chin, Suet-Feung; Rakha, Emad A; Green, Andrew R; Ellis, Ian O; Caldas, Carlos; O'Brien, Thomas; Friedman, Lori S; Koeppen, Hartmut; Rudolph, Joachim; Hoeflich, Klaus P.
Afiliação
  • Ong CC; Department of Translational Oncology, Genentech, Inc., South San Francisco, CA, USA. ong.christy@gene.com.
  • Gierke S; Department of Pathology, Genentech, Inc., South San Francisco, CA, USA. gierke.sarah@gene.com.
  • Pitt C; Department of Translational Oncology, Genentech, Inc., South San Francisco, CA, USA. cameron.pitt@ucsf.edu.
  • Sagolla M; New address: University of California, San Francisco, CA, USA. cameron.pitt@ucsf.edu.
  • Cheng CK; Department of Pathology, Genentech, Inc., South San Francisco, CA, USA. sagolla.meredith@gene.com.
  • Zhou W; Department of Translational Oncology, Genentech, Inc., South San Francisco, CA, USA. ccheng@cal.berkeley.edu.
  • Jubb AM; Department of Translational Oncology, Genentech, Inc., South San Francisco, CA, USA. zhou.wei@gene.com.
  • Strickland L; Department of Pathology, Genentech, Inc., South San Francisco, CA, USA. jubb.adrian@gene.com.
  • Schmidt M; Department of Diagnostics, Genentech, Inc., South San Francisco, CA, USA. sanders.laura@gene.com.
  • Duron SG; Department of Diagnostics, Genentech, Inc., South San Francisco, CA, USA. schmidt.maike@gene.com.
  • Campbell DA; Afraxis, La Jolla, CA, USA. sduron@coipharma.com.
  • Zheng W; New address: COI Pharmaceuticals, La Jolla, CA, USA. sduron@coipharma.com.
  • Dehdashti S; Afraxis, La Jolla, CA, USA. dcampbell@coipharma.com.
  • Shen M; New address: COI Pharmaceuticals, La Jolla, CA, USA. dcampbell@coipharma.com.
  • Yang N; National Center for Advancing Translational Sciences, Bethesda, MD, USA. wzheng@mail.nih.gov.
  • Behnke ML; National Center for Advancing Translational Sciences, Bethesda, MD, USA. seameen.dehdashti@fda.hhs.gov.
  • Huang W; New address: Food and Drug Administration, Silver Spring, MD, USA. seameen.dehdashti@fda.hhs.gov.
  • McKew JC; National Center for Advancing Translational Sciences, Bethesda, MD, USA. shenmin@mail.nih.gov.
  • Chernoff J; National Center for Advancing Translational Sciences, Bethesda, MD, USA. na.yang@nih.gov.
  • Forrest WF; National Center for Advancing Translational Sciences, Bethesda, MD, USA. mark.behnke@nih.gov.
  • Haverty PM; National Center for Advancing Translational Sciences, Bethesda, MD, USA. huangwe@mail.nih.gov.
  • Chin SF; National Center for Advancing Translational Sciences, Bethesda, MD, USA. john.mckew@gmail.com.
  • Rakha EA; New address: aTyr Pharma, San Diego, CA, USA. john.mckew@gmail.com.
  • Green AR; Fox Chase Cancer Center, Philadelphia, PA, USA. Jonathan.Chernoff@fccc.edu.
  • Ellis IO; Department of Biostatistics, Genentech, Inc., South San Francisco, CA, USA. forrest.bill@gene.com.
  • Caldas C; Department of Bioinformatics, Genentech, Inc., South San Francisco, CA, USA. haverty.peter@gene.com.
  • O'Brien T; Cancer Research UK, University of Cambridge, Cambridge, UK. Suet-Feung.Chin@cruk.cam.ac.uk.
  • Friedman LS; Histopathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospitals, Nottingham, UK. emadrakha@yahoo.com.
  • Koeppen H; Histopathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospitals, Nottingham, UK. Andrew.Green@nottingham.ac.uk.
  • Rudolph J; Histopathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospitals, Nottingham, UK. Ian.Ellis@nottingham.ac.uk.
  • Hoeflich KP; Cancer Research UK, University of Cambridge, Cambridge, UK. Carlos.Caldas@cruk.cam.ac.uk.
Breast Cancer Res ; 17: 59, 2015 Apr 23.
Article em En | MEDLINE | ID: mdl-25902869
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Apoptose / Inibidores de Proteínas Quinases / Moduladores de Tubulina / Quinases Ativadas por p21 / Microtúbulos Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Breast Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Apoptose / Inibidores de Proteínas Quinases / Moduladores de Tubulina / Quinases Ativadas por p21 / Microtúbulos Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Breast Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos