Evolution of the RAG1-RAG2 locus: both proteins came from the same transposon.
Biol Direct
; 10: 20, 2015 Apr 28.
Article
em En
| MEDLINE
| ID: mdl-25928409
ABSTRACT
The RAG1 and RAG2 proteins are essential subunits of the V(D)J recombinase that is required for the generation of the enormous variability of antibodies and T-cell receptors in jawed vertebrates. It was demonstrated previously that the 600-aa catalytic core of RAG1 evolved from the transposase of the Transib superfamily transposons. However, although homologs of RAG1 and RAG2 genes are adjacent in the purple sea urchin genome, a transposon encoding both proteins so far has not been reported. Here we describe such transposons in the genomes of green sea urchin, a starfish and an oyster. Comparison of the domain architectures of the RAG1 homologs in these transposons, denoted TransibSU, and other Transib superfamily transposases provides for reconstruction of the structure of the hypothetical TransibVDJ transposon that gave rise to the VDJ recombinases at the onset of vertebrate evolution some 500 million years ago.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Elementos de DNA Transponíveis
/
Proteínas de Homeodomínio
/
Evolução Molecular
/
Proteínas de Ligação a DNA
Limite:
Animals
Idioma:
En
Revista:
Biol Direct
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos