Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.

Ting, Pamela Y; Johnson, Christian W; Fang, Cong; Cao, Xiaoqing; Graeber, Thomas G; Mattos, Carla; Colicelli, John

Ting, Pamela Y; Johnson, Christian W; Fang, Cong; Cao, Xiaoqing; Graeber, Thomas G; Mattos, Carla; Colicelli, John.

Afiliação

Ting PY; *Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, U
Johnson CW; *Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, U
Fang C; *Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, U
Cao X; *Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, U
Graeber TG; *Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, U
Mattos C; *Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, U
Colicelli J; *Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, U

FASEB J ; 29(9): 3750-61, 2015 Sep.

Article em En | MEDLINE | ID: mdl-25999467

Assuntos

Proteínas Oncogênicas v-abl/metabolismo; Proteínas Proto-Oncogênicas p21(ras)/metabolismo; Transdução de Sinais/fisiologia; Substituição de Aminoácidos; Animais; Células HEK293; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/química; Peptídeos e Proteínas de Sinalização Intracelular/genética; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Mutação de Sentido Incorreto; Proteínas Oncogênicas v-abl/química; Proteínas Oncogênicas v-abl/genética; Fosforilação/genética; Proto-Oncogene Mas; Proteínas Proto-Oncogênicas p21(ras)/química; Proteínas Proto-Oncogênicas p21(ras)/genética; Ratos; Tirosina/química; Tirosina/genética; Tirosina/metabolismo; Proteínas rab5 de Ligação ao GTP/química; Proteínas rab5 de Ligação ao GTP/genética; Proteínas rab5 de Ligação ao GTP/metabolismo; Quinases raf/química; Quinases raf/genética; Quinases raf/metabolismo

Palavras-chave

GTPase; RAF1; RIN1; signal transduction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas Oncogênicas v-abl / Proteínas Proto-Oncogênicas p21(ras) Limite: Animals / Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2015 Tipo de documento: Article

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