Association of the interleukin-6 polymorphisms with systemic lupus erythematosus: a meta-analysis.
Lupus
; 24(12): 1308-17, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26038346
ABSTRACT
BACKGROUND:
Interleukin (IL)-6, an important proinflammatory cytokine, plays a potential pathological role in systemic lupus erythematosus (SLE). Studies on the relationship of IL-6 gene polymorphisms with SLE are inconclusive. The aim of this study was to estimate the relationship more precisely.METHODS:
The databases of PubMed and Web of Science updated to 30 August 2014 were retrieved. Meta-analysis was conducted using allelic contrast, dominant, recessive and homozygote contrast models. Fifteen studies were included in this study and ethnicity-specific meta-analysis was performed on European, Iranian and Asian populations.RESULTS:
Analysis for the IL-6-174 G/C polymorphism under all models except the homozygote contrast model indicated an association in the overall population (allelic contrast model odds ratio (OR) 1.428, 95% confidence interval (CI) 1.124-1.812, dominant model OR 1.382, 95% CI 1.037-1.842, recessive model OR 1.610, 95% CI 1.158-2.240, homozygote contrast model OR 1.759, 95% CI 0.989-3.127), as well as in European individuals under all four genetic models (allelic contrast model OR 1.557, 95% CI 1.155-2.098, dominant model OR 1.699, 95% CI 1.203-2.400, recessive model OR 1.506, 95% CI 1.176-1.930, homozygote contrast model OR 2.118, 95% CI 1.103-4.065). Analysis for the IL-6-572 G/C polymorphism indicated significant association in overall ethnicities under the recessive model (OR 1.491, 95% CI 1.104-2.014), but not under other models or in Asian individuals. In addition, significant association between the IL-6-174 G/C polymorphism and discoid skin lesions and antinuclear antibodies (ANAs) were found under the allelic contrast model and recessive model, respectively (discoid skin lesions OR 2.271, 95% CI 1.053-4.895; ANAs OR 2.244, 95% CI 1.141-4.416).CONCLUSION:
This meta-analysis provides evidence of the association between the IL-6 polymorphism and the risk of SLE, hinting that the IL-6-174 G/C and IL-6-572 G/C polymorphisms may play a role in SLE susceptibility.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Antinucleares
/
Interleucina-6
/
População Branca
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Lupus
Assunto da revista:
REUMATOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
China