Effects of co-administration of 2-arachidonylglycerol (2-AG) and a selective µ-opioid receptor agonist into the nucleus accumbens on high-fat feeding behaviors in the rat.
Brain Res
; 1618: 309-15, 2015 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-26100333
ABSTRACT
Previous research has demonstrated that the nucleus accumbens is a site where opioids and cannabinoids interact to alter feeding behavior. However, the influence of the endocannabinoid 2-arachidonylglycerol (2-AG) on the well-characterized model of intra-accumbens opioid driven high-fat feeding behavior has not been explored. The present experiments examined high-fat feeding associated behaviors produced by the interaction of 2-AG and the µ-opioid receptor agonist DAla(2),N,Me-Phe(4),Gly-ol(5)-enkaphalin (DAMGO) administered into the nucleus accumbens. Sprague-Dawley rats were implanted with bilateral cannulae aimed at the nucleus accumbens and were co-administered both a sub-threshold dose of 2-AG (0 or 0.25 µg/0.5 µl/side) and DAMGO (0, 0.025 µg or 0.25 µg/0.5 µl/side) in all dose combinations, and in a counterbalanced order. Animals were then immediately allowed a 2h-unrestricted access period to a palatable high-fat diet. Consumption, number and duration of food hopper entries, and locomotor activity were all monitored. DAMGO treatment led to an increase in multiple behaviors, including consumption, duration of food hopper entry, and locomotor activity. However, combined intra-accumbens administration of DAMGO and a subthreshold dose of 2-AG led to a significant increase in number of food hopper entries and locomotor activity, compared to DAMGO by itself. The results confirm that intra-accumbens administration of subthreshold dose of the endogenous cannabinoid 2-AG increases the DAMGO-induced approach and locomotor behaviors associated with high-fat feeding.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Gorduras na Dieta
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Ácidos Araquidônicos
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Ala(2)-MePhe(4)-Gly(5)-Encefalina
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Endocanabinoides
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Comportamento Alimentar
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Agonistas de Receptores de Canabinoides
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Glicerídeos
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Analgésicos Opioides
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Núcleo Accumbens
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos