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Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors.
Lemon, Christopher M; Karnas, Elizabeth; Han, Xiaoxing; Bruns, Oliver T; Kempa, Thomas J; Fukumura, Dai; Bawendi, Moungi G; Jain, Rakesh K; Duda, Dan G; Nocera, Daniel G.
Afiliação
  • Lemon CM; †Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
  • Karnas E; ‡Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Han X; ‡Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Bruns OT; §Edwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Cox-7, Boston, Massachusetts 02114, United States.
  • Kempa TJ; ‡Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Fukumura D; †Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
  • Bawendi MG; §Edwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Cox-7, Boston, Massachusetts 02114, United States.
  • Jain RK; ‡Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Duda DG; §Edwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Cox-7, Boston, Massachusetts 02114, United States.
  • Nocera DG; §Edwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Cox-7, Boston, Massachusetts 02114, United States.
J Am Chem Soc ; 137(31): 9832-42, 2015 Aug 12.
Article em En | MEDLINE | ID: mdl-26149349
ABSTRACT
Micelles have been employed to encapsulate the supramolecular assembly of quantum dots with palladium(II) porphyrins for the quantification of O2 levels in aqueous media and in vivo. Förster resonance energy transfer from the quantum dot (QD) to the palladium porphyrin provides a means for signal transduction under both one- and two-photon excitation. The palladium porphyrins are sensitive to O2 concentrations in the range of 0-160 Torr. The micelle-encapsulated QD-porphyrin assemblies have been employed for in vivo multiphoton imaging and lifetime-based oxygen measurements in mice with chronic dorsal skinfold chambers or cranial windows. Our results establish the utility of the QD-micelle approach for in vivo biological sensing applications.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Técnicas de Química Analítica / Fótons / Pontos Quânticos / Metaloporfirinas / Micelas Limite: Animals Idioma: En Revista: J Am Chem Soc Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Técnicas de Química Analítica / Fótons / Pontos Quânticos / Metaloporfirinas / Micelas Limite: Animals Idioma: En Revista: J Am Chem Soc Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos