Dietary Intakes of Folic Acid and Methionine in Early Childhood Are Associated with Body Composition at School Age.
J Nutr
; 145(9): 2123-9, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26203097
ABSTRACT
BACKGROUND:
Deficiency of vitamin B-6, vitamin B-12, folate, folic acid, or methionine may lead to dysregulation of DNA methylation, which might lead to disturbed energy and lipid metabolism.OBJECTIVE:
We aimed to explore whether intakes of vitamin B-6, vitamin B-12, folate, folic acid, and methionine at 1 y are associated with measures of growth and body composition at the age of 6 y.METHODS:
This study was performed in 2922 children participating in The Generation R Study, a population-based prospective cohort study. Dietary intakes of vitamins B-6 and B-12, folate, folic acid, and methionine were assessed at a median age of 12.9 mo by using a validated food-frequency questionnaire. At the age of 6 y, height and weight were measured, and body mass index (BMI; in kg/m(2)) was calculated. Body fat was measured with dual-energy X-ray absorptiometry, and body fat percentage and the ratio of android fat mass to gynoid fat mass (androidgynoid) were calculated.RESULTS:
In models adjusted for maternal and child characteristics, children with folic acid intakes in the highest tertile had a 0.16 SD score (SDS) lower weight (95% CI -0.31, -0.02 SDS) and a 0.14 SDS lower BMI (95% CI -0.26, -0.01 SDS) than children in the lowest tertile. Children with vitamin B-12 intakes in the highest tertile had a 0.13 SDS higher androidgynoid (95% CI 0.00, 0.25 SDS) than children in the lowest tertile. In addition, children with intakes in the highest tertile of methionine had a 0.09 SDS higher BMI (95% CI 0.01, 0.17) and a 0.12 SDS higher androidgynoid (95% CI 0.02, 0.22) than children in the lowest tertile. Vitamin B-6 and folate intakes were not associated with any of the body composition outcomes measured.CONCLUSIONS:
In this population of children, early high folic acid intakes were associated with a lower body weight and BMI at the age of 6 y. In contrast, early higher methionine intakes were associated with unfavorable body composition at the age of 6 y. Future studies should investigate long-term consequences of these outcomes on health.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Composição Corporal
/
Fenômenos Fisiológicos da Nutrição Infantil
/
Ácido Fólico
/
Metionina
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Nutr
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Holanda