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Severe Influenza in 33 US Hospitals, 2013-2014: Complications and Risk Factors for Death in 507 Patients.
Shah, Nirav S; Greenberg, Jared A; McNulty, Moira C; Gregg, Kevin S; Riddell, James; Mangino, Julie E; Weber, Devin M; Hebert, Courtney L; Marzec, Natalie S; Barron, Michelle A; Chaparro-Rojas, Fredy; Restrepo, Alejandro; Hemmige, Vagish; Prasidthrathsint, Kunatum; Cobb, Sandra; Herwaldt, Loreen; Raabe, Vanessa; Cannavino, Christopher R; Hines, Andrea Green; Bares, Sara H; Antiporta, Philip B; Scardina, Tonya; Patel, Ursula; Reid, Gail; Mohazabnia, Parvin; Kachhdiya, Suresh; Le, Binh-Minh; Park, Connie J; Ostrowsky, Belinda; Robicsek, Ari; Smith, Becky A; Schied, Jeanmarie; Bhatti, Micah M; Mayer, Stockton; Sikka, Monica; Murphy-Aguilu, Ivette; Patwari, Priti; Abeles, Shira R; Torriani, Francesca J; Abbas, Zainab; Toya, Sophie; Doktor, Katherine; Chakrabarti, Anindita; Doblecki-Lewis, Susanne; Looney, David J; David, Michael Z.
Afiliação
  • Shah NS; 1Department of Medicine,University of Chicago,Chicago,Illinois.
  • Greenberg JA; 1Department of Medicine,University of Chicago,Chicago,Illinois.
  • McNulty MC; 1Department of Medicine,University of Chicago,Chicago,Illinois.
  • Gregg KS; 2Department of Medicine,University of Michigan Medical School,Ann Arbor,Michigan.
  • Riddell J; 2Department of Medicine,University of Michigan Medical School,Ann Arbor,Michigan.
  • Mangino JE; 3Department of Medicine,Ohio State University Wexner Medical Center,Columbus,Ohio.
  • Weber DM; 3Department of Medicine,Ohio State University Wexner Medical Center,Columbus,Ohio.
  • Hebert CL; 3Department of Medicine,Ohio State University Wexner Medical Center,Columbus,Ohio.
  • Marzec NS; 5Department of Medicine,University of Colorado Denver,Denver,Colorado.
  • Barron MA; 5Department of Medicine,University of Colorado Denver,Denver,Colorado.
  • Chaparro-Rojas F; 6Department of Medicine,Vidant Medical Center,Greenville,North Carolina.
  • Restrepo A; 7Department of Medicine,Baylor College of Medicine,Houston,Texas.
  • Hemmige V; 7Department of Medicine,Baylor College of Medicine,Houston,Texas.
  • Prasidthrathsint K; 8Department of Medicine,University of Iowa Hospitals and Clinics,Iowa City,Iowa.
  • Cobb S; 8Department of Medicine,University of Iowa Hospitals and Clinics,Iowa City,Iowa.
  • Herwaldt L; 8Department of Medicine,University of Iowa Hospitals and Clinics,Iowa City,Iowa.
  • Raabe V; 9Department of Pediatrics,University of California San Diego and Rady Children's Hospital San Diego,San Diego,California.
  • Cannavino CR; 9Department of Pediatrics,University of California San Diego and Rady Children's Hospital San Diego,San Diego,California.
  • Hines AG; 10Department of Medicine,University of Nebraska Medical Center,Omaha,Nebraska.
  • Bares SH; 10Department of Medicine,University of Nebraska Medical Center,Omaha,Nebraska.
  • Antiporta PB; 11Department of Medicine,Loyola University Medical Center,Maywood,Illinois.
  • Scardina T; 13Department of Pharmacy,Loyola University Medical Center,Maywood,Illinois.
  • Patel U; 14Department of Pharmacy,Edward Hines VA Hospital,Maywood,Illinois.
  • Reid G; 11Department of Medicine,Loyola University Medical Center,Maywood,Illinois.
  • Mohazabnia P; 15Department of Medicine,University of Texas Southwestern Medical Center,Dallas,Texas.
  • Kachhdiya S; 15Department of Medicine,University of Texas Southwestern Medical Center,Dallas,Texas.
  • Le BM; 15Department of Medicine,University of Texas Southwestern Medical Center,Dallas,Texas.
  • Park CJ; 16Department of Medicine,Montefiore Medical Center/Albert Einstein College of Medicine,Bronx,New York.
  • Ostrowsky B; 16Department of Medicine,Montefiore Medical Center/Albert Einstein College of Medicine,Bronx,New York.
  • Robicsek A; 1Department of Medicine,University of Chicago,Chicago,Illinois.
  • Smith BA; 17Department of Medicine,Northshore University HealthSystem,Evanston,Illinois.
  • Schied J; 18Department of Pediatrics,University of Chicago,Chicago,Illinois.
  • Bhatti MM; 18Department of Pediatrics,University of Chicago,Chicago,Illinois.
  • Mayer S; 19Department of Medicine,University of Illinois at Chicago,Chicago,Illinois.
  • Sikka M; 19Department of Medicine,University of Illinois at Chicago,Chicago,Illinois.
  • Murphy-Aguilu I; 19Department of Medicine,University of Illinois at Chicago,Chicago,Illinois.
  • Patwari P; 21Department of Medicine,Community Care Networks,Munster,Indiana.
  • Abeles SR; 22Department of Medicine,University of California San Diego,San Diego,California.
  • Torriani FJ; 22Department of Medicine,University of California San Diego,San Diego,California.
  • Abbas Z; 23Department of Medicine,Methodist Hospitals,Merrillville,Indiana.
  • Toya S; 23Department of Medicine,Methodist Hospitals,Merrillville,Indiana.
  • Doktor K; 24Department of Medicine,University of Miami/Jackson Health System,Miami,Florida.
  • Chakrabarti A; 24Department of Medicine,University of Miami/Jackson Health System,Miami,Florida.
  • Doblecki-Lewis S; 24Department of Medicine,University of Miami/Jackson Health System,Miami,Florida.
  • Looney DJ; 25Department of Medicine,VA San Diego/University of California San Diego,San Diego,California.
  • David MZ; 1Department of Medicine,University of Chicago,Chicago,Illinois.
Infect Control Hosp Epidemiol ; 36(11): 1251-60, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26224364
BACKGROUND: Influenza A (H1N1) pdm09 became the predominant circulating strain in the United States during the 2013-2014 influenza season. Little is known about the epidemiology of severe influenza during this season. METHODS: A retrospective cohort study of severely ill patients with influenza infection in intensive care units in 33 US hospitals from September 1, 2013, through April 1, 2014, was conducted to determine risk factors for mortality present on intensive care unit admission and to describe patient characteristics, spectrum of disease, management, and outcomes. RESULTS: A total of 444 adults and 63 children were admitted to an intensive care unit in a study hospital; 93 adults (20.9%) and 4 children (6.3%) died. By logistic regression analysis, the following factors were significantly associated with mortality among adult patients: older age (>65 years, odds ratio, 3.1 [95% CI, 1.4-6.9], P=.006 and 50-64 years, 2.5 [1.3-4.9], P=.007; reference age 18-49 years), male sex (1.9 [1.1-3.3], P=.031), history of malignant tumor with chemotherapy administered within the prior 6 months (12.1 [3.9-37.0], P<.001), and a higher Sequential Organ Failure Assessment score (for each increase by 1 in score, 1.3 [1.2-1.4], P<.001). CONCLUSION: Risk factors for death among US patients with severe influenza during the 2013-2014 season, when influenza A (H1N1) pdm09 was the predominant circulating strain type, shifted in the first postpandemic season in which it predominated toward those of a more typical epidemic influenza season.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Influenza Humana / Vírus da Influenza A Subtipo H1N1 Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: America do norte Idioma: En Revista: Infect Control Hosp Epidemiol Assunto da revista: DOENCAS TRANSMISSIVEIS / ENFERMAGEM / EPIDEMIOLOGIA / HOSPITAIS Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Influenza Humana / Vírus da Influenza A Subtipo H1N1 Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: America do norte Idioma: En Revista: Infect Control Hosp Epidemiol Assunto da revista: DOENCAS TRANSMISSIVEIS / ENFERMAGEM / EPIDEMIOLOGIA / HOSPITAIS Ano de publicação: 2015 Tipo de documento: Article