Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.

Leclerc, Guy J; DeSalvo, Joanna; Du, Jianfeng; Gao, Ningguo; Leclerc, Gilles M; Lehrman, Mark A; Lampidis, Theodore J; Barredo, Julio C

Leclerc, Guy J; DeSalvo, Joanna; Du, Jianfeng; Gao, Ningguo; Leclerc, Gilles M; Lehrman, Mark A; Lampidis, Theodore J; Barredo, Julio C.

Afiliação

Leclerc GJ; Department of Pediatrics, Division of Hematology and Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
DeSalvo J; Department of Pediatrics, Division of Hematology and Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
Du J; Department of Pediatrics, Division of Hematology and Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
Gao N; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Leclerc GM; Department of Pediatrics, Division of Hematology and Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
Lehrman MA; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Lampidis TJ; Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL 33101, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
Barredo JC; Department of Pediatrics, Division of Hematology and Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33101, USA; Department of Biochemistry and Molecular Biology, University

Leuk Res ; 2015 Aug 20.

Article em En | MEDLINE | ID: mdl-26346348

Palavras-chave

2-deoxy-d-glucose; AMPK; Acute lymphoblastic leukemia; Apoptosis; BCR-ABL+; Combination targeted therapy; Dasatinib; ER stress; ERK; Energy stress; Imatinib; Leukemia; Mcl-1; Tyrosine kinase inhibitors; UPR; eIF2α; shRNA

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Leuk Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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