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Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.
Bolduc, David M; Montagna, Daniel R; Gu, Yongli; Selkoe, Dennis J; Wolfe, Michael S.
Afiliação
  • Bolduc DM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Montagna DR; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Gu Y; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Selkoe DJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 mswolfe@partners.org dselkoe@partners.org.
  • Wolfe MS; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 mswolfe@partners.org dselkoe@partners.org.
Proc Natl Acad Sci U S A ; 113(5): E509-18, 2016 Feb 02.
Article em En | MEDLINE | ID: mdl-26699478
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Secretases da Proteína Precursora do Amiloide Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Secretases da Proteína Precursora do Amiloide Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article