Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides.

Dixon, James E; Osman, Gizem; Morris, Gavin E; Markides, Hareklea; Rotherham, Michael; Bayoussef, Zahia; El Haj, Alicia J; Denning, Chris; Shakesheff, Kevin M

Dixon, James E; Osman, Gizem; Morris, Gavin E; Markides, Hareklea; Rotherham, Michael; Bayoussef, Zahia; El Haj, Alicia J; Denning, Chris; Shakesheff, Kevin M.

Afiliação

Dixon JE; School of Pharmacy, Wolfson Centre for Stem Cells, Tissue Engineering, and Modelling, Centre of Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, United Kingdom; Kevin.Shakesheff@nottingham.ac.uk james.dixon@nottingham.ac.uk.
Osman G; School of Pharmacy, Wolfson Centre for Stem Cells, Tissue Engineering, and Modelling, Centre of Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, United Kingdom;
Morris GE; School of Pharmacy, Wolfson Centre for Stem Cells, Tissue Engineering, and Modelling, Centre of Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, United Kingdom;
Markides H; Institute of Science and Technology in Medicine, Guy Hilton Research Centre, Keele University, Stoke-on-Trent, ST4 7QB, United Kingdom;
Rotherham M; Institute of Science and Technology in Medicine, Guy Hilton Research Centre, Keele University, Stoke-on-Trent, ST4 7QB, United Kingdom;
Bayoussef Z; School of Pharmacy, Wolfson Centre for Stem Cells, Tissue Engineering, and Modelling, Centre of Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, United Kingdom;
El Haj AJ; Institute of Science and Technology in Medicine, Guy Hilton Research Centre, Keele University, Stoke-on-Trent, ST4 7QB, United Kingdom;
Denning C; School of Medicine, Wolfson Centre for Stem Cells, Tissue Engineering, and Modelling, Centre of Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, United Kingdom.
Shakesheff KM; School of Pharmacy, Wolfson Centre for Stem Cells, Tissue Engineering, and Modelling, Centre of Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, United Kingdom; Kevin.Shakesheff@nottingham.ac.uk james.dixon@nottingham.ac.uk.

Proc Natl Acad Sci U S A ; 113(3): E291-9, 2016 Jan 19.

Article em En | MEDLINE | ID: mdl-26733682

Assuntos

Peptídeos Penetradores de Células/metabolismo; Sistemas de Liberação de Medicamentos; Glicosaminoglicanos/metabolismo; Motivos de Aminoácidos; Animais; Diferenciação Celular/efeitos dos fármacos; Membrana Celular/efeitos dos fármacos; Membrana Celular/metabolismo; Proliferação de Células/efeitos dos fármacos; Peptídeos Penetradores de Células/química; Detergentes/farmacologia; Endocitose/efeitos dos fármacos; Genoma; Proteínas de Homeodomínio/metabolismo; Células-Tronco Embrionárias Humanas/citologia; Células-Tronco Embrionárias Humanas/efeitos dos fármacos; Células-Tronco Embrionárias Humanas/metabolismo; Humanos; Células-Tronco Pluripotentes Induzidas/efeitos dos fármacos; Células-Tronco Pluripotentes Induzidas/metabolismo; Integrases/metabolismo; Camundongos; Células-Tronco Embrionárias Murinas/citologia; Células-Tronco Embrionárias Murinas/efeitos dos fármacos; Células-Tronco Embrionárias Murinas/metabolismo; Desenvolvimento Muscular/efeitos dos fármacos; Proteína MyoD/metabolismo; Células NIH 3T3; Proteína Homeobox Nanog; Nanopartículas; Ácidos Nucleicos/metabolismo; Estrutura Terciária de Proteína; Solubilidade; Tripsina/metabolismo

Palavras-chave

cell-penetrating peptides; differentiation; heparin-binding domain; human embryonic stem cells; transduction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Peptídeos Penetradores de Células / Glicosaminoglicanos Tipo de estudo: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article

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