Preclinical Anticancer Efficacy of BET Bromodomain Inhibitors Is Determined by the Apoptotic Response.

Conery, Andrew R; Centore, Richard C; Spillane, Kerry L; Follmer, Nicole E; Bommi-Reddy, Archana; Hatton, Charlie; Bryant, Barbara M; Greninger, Patricia; Amzallag, Arnaud; Benes, Cyril H; Mertz, Jennifer A; Sims, Robert J

Conery, Andrew R; Centore, Richard C; Spillane, Kerry L; Follmer, Nicole E; Bommi-Reddy, Archana; Hatton, Charlie; Bryant, Barbara M; Greninger, Patricia; Amzallag, Arnaud; Benes, Cyril H; Mertz, Jennifer A; Sims, Robert J.

Afiliação

Conery AR; Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts.
Centore RC; Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts.
Spillane KL; Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts.
Follmer NE; Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts.
Bommi-Reddy A; Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts.
Hatton C; Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts.
Bryant BM; Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts.
Greninger P; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Amzallag A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Benes CH; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Mertz JA; Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts.
Sims RJ; Constellation Pharmaceuticals, Inc., Cambridge, Massachusetts. robert.Sims@constellationpharma.com.

Cancer Res ; 76(6): 1313-9, 2016 Mar 15.

Article em En | MEDLINE | ID: mdl-26759243

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Bibliotecas de Moléculas Pequenas/farmacologia; Proteínas Reguladoras de Apoptose/metabolismo; Linhagem Celular Tumoral; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Células HCT116; Células HL-60; Células HT29; Humanos; Células K562; Leucemia/tratamento farmacológico; Leucemia/metabolismo; Melanoma/tratamento farmacológico; Melanoma/metabolismo; Transdução de Sinais/efeitos dos fármacos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Bibliotecas de Moléculas Pequenas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cancer Res Ano de publicação: 2016 Tipo de documento: Article

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